The Flood is an event Enoch seeks to prevent in El Shaddai: Ascension of the Metatron.
The Council of Elders decides to unleash a second great flood upon the Earth in response to the theft of the Fruits of Wisdom by the Grigori. The decision is postponed by God who offers Enoch a chance to prevent it by defeating and capturing the Grigori.
Lucifel reveals God mainly wants The Flood to rid the world of the Nephilim, abominations that could become the destructive Fire Nephilim and destroy the world.